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TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

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Immunofluorescence staining was conducted to assess antioxidant capacity via SOD expression and to evaluate macrophage polarization using CD86 (M1 marker) and CD206 (M2 marker)

A literature search was conducted using the keywords peptides OR exosomes AND skin OR rejuvenation. Primary endpoints included mechanisms of action in humans or live animals as well as clinical data supporting the use of exosomes or peptides topically for skin rejuvenation or wound healing

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