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doi: 10.3389/fphar.2026.1762214 Received 06 December 2025 Revised 15 January 2026 Accepted 15 January 2026 Published 09 February 2026 Volume 17 - 2026 Edited by Exequiel Oscar Jesus Porta, University College London, United Kingdom Reviewed by Omobolanle Omoteso, Rhodes University Biopharmaceutical Research Institute, South Africa Mubanga Chipimo, Ministry of Health, Lusaka Zambia, Zambia Updates Copyright 2026 Zhang, Cheng and Tang

Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins attributed to the action of leucoanthocyanidin dioxygenase has never been efficiently reconstituted outside plants, preventing the construction of heterologous cell factories
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