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74 Screening and monitoring of vitamin B12 status are not routinely performed in those being administered metformin and the authors propose that it should, particularly since deficiencies are frequently asymptomatic and neuropathy is frequently irreversible

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Vitamin B12 supplementation can increase serum B12 concentrations in users of metformin [47,52], but it remains unclear whether it may reduce neuropathy risk

The honest assessment is this: choosing AOD-9604 over semaglutide as a primary weight management strategy is not supported by the clinical evidence