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All SAEs of death, development of signs of critical illness and severe illness requiring hospitalisation, and AEs as described previously will be reported to the Ethics Committees, the Data and Safety Monitoring Board (DSMB) and to the sponsors of the study within 24 hours of awareness of the event, followed by a final report within 10 days

The involvement of Src in D2-like receptor desensitization was further confirmed by using D2-like receptor mutants with different desensitization properties (Additional file 1: Fig

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Conjugation refers to the addition or coming together of compounds in order to neutralize toxins, making them more easily excreted through the urine or bile

In the presence of a large amount of NO, O 2 produced by XO generates ONOO, which then decomposes into nitrogen dioxide free radicals (NO 2 ) and OH, which in turn nitrates tyrosine residues and affects intracellular signaling (42)

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