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In the central nervous system, niacin is known as a key mediator of neuronal development and survival (37)

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doi: 10.1038/pr.2017.227, PMID: [DOI] [PubMed] [Google Scholar] 48.Kidokoro H, Anderson PJ, Doyle LW, Woodward LJ, Neil JJ, Inder TE

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In addition to these physiologic signs of withdrawal, a constellation of symptoms contributing to psychologic discomfort and negative affect constitutes a prominent component of the withdrawal syndrome