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Recent findings reinforce the promising synergistic effects of VitC with kinase inhibitors such as BRAFV600 inhibitor PLX4032 in thyroid cancer in vivo [64] and with BTK inhibitor ibrutinib and PI3K inhibitor idelalisib in chronic lymphocytic leukemia (CLL) patient-derived cells [104]

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Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia

Current pharmacological interventions for oxidative stress in the nervous systemsuch as edaravone (15, 16) and N-acetylcysteine (16, 17)act on single targets and employ relatively narrow mechanisms, and are associated with dose-limiting adverse effects and loss-of-benefit phenomena (e.g., end-of-dose deterioration and motor complications), rather than durable disease modification (18)

This receptor not only governs food intake but also plays a crucial role in managing metabolism

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