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In addition, TMA is formed by the Cys 771 promoting cleavage of choline through a radical exchange with the alpha carbon to form alcohol in the formation of acetaldehyde and TMA ( FIGURE 1 (B) Choline bound to TMA lyase showing key binding interactions with active site amino acid residues that occur upon activation PDB 5AOU

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J., Voytas, D

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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Beigneux AP, et al

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10.1016/S0893-133X(02)00306-8 97

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