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Changes seen in liver tissue samples were scored as none, light, moderate, and significant, as described (108)

Of the three haplotypes, the upstream genetic alterations that were in linkage disequilibrium with the Leu allele were also found to have the lowest level of activity in a transcription reporter gene assay, causing a 25% suppression in promoter activity (152)

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At the same time, endothelial cell senescence also affects the delivery of nutrients and oxygen, leading to metabolic abnormalities and further accelerating organismal aging (Boutouyrie et al., 2021

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