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When the active, reduced form of glutathione (GSH) encounters a reactive oxygen species (ROS)such as a superoxide anion or a hydroxyl radicalit donates a reducing equivalent (an electron or hydrogen atom) to neutralize the threat

62 Thus, consistent with the very low levels of LPO, 55,62 lysosomal ferrous iron translocated into mitochondria promotes MPTP opening and APAP-induced cell death through facilitation of protein nitration, rather than generation of LPO under normal conditions

In Huh7.5 cells infected by HCV genotype 2 an increase in GSSG and a decrease of GSH has been observed by Roe et al

Panayiotidis MI

Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control