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Nrf2 not only increases the enzyme levels of both the oxidative and non-oxidative arms, but it also facilitates the utilization of ribose 5-phosphate for the purine nucleotide synthesis (Mitsuishi et al., 2012), which appears to maintain the ribose 5-phosphate concentration at a low level and efficiently divert glucose flux into purine nucleotide synthesis through both arms of the pentose phosphate pathway

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10.1016/0024-3205(93)90589-u [DOI] [PubMed] [Google Scholar] Sikiric P., Seiwerth S., Rucman R., Kolenc D., Vuletic L

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APOE and Alzheimers disease: from lipid transport to physiopathology and therapeutics

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