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Specifically, these two regulate the cells entry into the proliferative phase (division)

This rapid proliferation has two requirements that depend critically on B12: 1

First, polar aggregation induced by an armed mAb results in a significant re-distribution of CD38 on the membrane and a marked reduction in its expression

Elevated B12 levels themselves rarely cause direct symptoms

The parent protein was identified during investigations of compounds in human gastric juice that conferred protection against ulceration, and the active 15-residue fragment retained the full activity of the larger protein in subsequent characterisation studies

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