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Though these techniques have been proven effective, their brain-targeting efficiency and safety need further improvement
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18 Furthermore, antibiotics to eliminate these pathogens, as well as other medicines that negatively impact the gut microbiome, have been found to increase gut epithelium oxidation due to altered microbial composition and metabolic signaling to the host
This disruption helps the biofilm become susceptible to removal from whatever type of surface it is attached on
Conversely, ferroptotic cells release DAMPs that activate neutrophils, amplifying inflammation (108)

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