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A deficiency can also cause a condition called megaloblastic anemia which creates larger, immature, and abnormal red blood cells and leads to impaired DNA synthesis

Nat Rev Nephrol 22 , 137151 (2026)

On one hand, ROS target mitochondrial membrane phospholipids, resulting in lipid peroxidation and impairing the function of the respiratory chain complexes (Chen S

Pharmacological Inhibition of Cystine-Glutamate Exchange Induces Endoplasmic Reticulum Stress and Ferroptosis

In the former case, attention is focused on the first key enzyme of GSH synthesis, GLCL, and in the latter case on GSTs

22 , 4452 (1999) Blanchet, E