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Addressing underlying causes is essential: Dietary modification and supplementation for vegans/vegetarians Management of gastrointestinal disorders affecting absorption Screening for coeliac disease if indicated Review of medications that may contribute to deficiencypatients should not stop prescribed medications such as metformin or proton pump inhibitors without consulting their doctor For patients on long-term metformin, the MHRA recommends considering vitamin B12 testing in those with symptoms or risk factors for deficiency, with periodic monitoring in at-risk groups

To explore the loss of DAergic neurons in MPTP-treated PD mice, immunofluorescence staining and immunoblotting results showed EPS intervention for 8 days could ameliorate the MPTP-induced DAergic neuron loss and increase TH protein expression (Fig

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Topicals are low barrier entry, microneedling can raise penetration, and injections or mesotherapy require clinic sterility and close follow-up

But, these findings might not apply to humans