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Indeed, in this preclinical study of glioma, EphB4 overexpression was associated with alterations in vascular morphogenesis, pericyte coverage, cellular proliferation and apoptosis, inducing a vascular phenotype resistant to therapy
[112] [105] Like other TCAs, clomipramine weakly blocks voltage-dependent sodium channels as well
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Disease relapse, however, can be more rapid and aggressive than disease in the initial phase
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