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82 Risk factors for recurrence include male sex, age younger than 16 years, residence in urban areas, cumulative oral retinoid dose greater than 2,450mg, and treatment duration longer than 121 days

A maximum drop of 81% in MA was measured in 4 h biofilms post-exposure to HICA (OD 492

This makes it potentially safer than phytoestrogens for women in whom estrogen stimulation is a concern, though the evidence base is smaller and the standardization of commercial products is inconsistent

However, the specific mechanism by which androgens regulate mitochondrial cristae is not yet clear, and the regulation of the expression of genes related to the mitochondrial cristae structure, such as optical atrophy and cardiolipin, may be included, but further studies are needed to confirm this