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The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network

Additionally, the CheckMate 18 phase III clinical trial, focusing on individuals with inoperable or metastatic melanoma, revealed a 43.6% objective response rate (ORR) in PD-L1-positive patients treated with nivolumab, compared to 9.1% in those receiving chemotherapy [116]

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In mammalian cells, SESTRIN2 interacts with ULK1 and facilitates ULK1-mediated phosphorylation of BECLIN1, which is required for BECLIN1 binding with PARKIN prior to mitochondrial translocation

childhood AD, occurring from 2 to 10 years

Wang H, Chen Y, Zhai N, Chen X, Gan F, Li H, et al