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Echinatin in ESCC cells induced arrest at the G2/M phase of the cell cycle associated with cyclin B1, and cdc2 downregulation with the current upregulation of p21 and p27 proteins

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Another aspect supporting the use of budesonide is its high first-pass effect (over 90%), which minimizes its side effects and makes it better tolerated than traditional steroids [29]

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Drug solubility: importance and enhancement techniques