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Proteoforms that increased in abundance with worsening neuropathology included, unsurprisingly, those derived from amyloid precursor protein (APP)

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Anticonvulsant and antioxidant effects of lamotrigine on pilocarpine-induced status epilepticus in mice

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In PDAC, the overexpression of cytochrome P450 2J2 (CYP2J2) leads to elevated levels of 8,9-DHET, which upregulates FSP1 mRNA and contributes to ferroptosis resistance in PDAC

However, it displayed increased mobility in the forced swim test and reduced sociability in the social interaction test, showing similarity to GAD67 conventional heterozygous knockout mice