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For example, O 2 triggers the intracellular p38 MAPK and JNK pathways, promoting apoptosis while also generating other ROS (such as H 2 O 2 ) to further amplify oxidative damage [218]

doi: 10.1007/s00726-017-2389-2

Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis

Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity

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2.2 Intake of vitamin E through supplementation It is clear from the above that with a normal diet it is not possible to have too high an intake of vitamin E to cause adverse effects