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Notably, elevated ratios of long-chain to very long-chain ceramide species in BALF correlate with inflammatory markers and lung disease severity, mechanistically linked to enhanced bacterial susceptibility and epithelial apoptosis (Zhang et al., 2008

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aeruginosa can induce ferroptotic cell death in human bronchial epithelial cells by expressing lipoxygenase (pLoxA), which can oxidize host PE-AA to 15-HpETE ( P