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While injectable GLP-1-based therapy uptake has been well documented ( 8 ), far less is known about how quickly newly approved obesity therapies are adopted in routine clinical practice, particularly in the weeks immediately following approval

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What is medically necessary should be determined by a doctor and their patientnot dictated by insurers

Cleavage of SDF-1 by DPP-4 results in loss of activity (65), and consistent with this, DPP-4 inhibition in humans has been associated with enhancement of some effects which are associated with SDF-1 [increased levels of circulating endothelial progenitor cells (66) and increased distal tube sodium excretion (64)]