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Large studies agree with this
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These links reflect shared immunogenetic factors, including IL-18, IFN-, CTLA-4, HLA-DQ8, HLA-DQ2, HLA-B8, and HLA-DR3, many of which are integral to antigen presentation within the major histocompatibility complex (MHC)
Specifically, a threefold increase in neutrophil count, a twofold increase in protease levels, and 2-4 times higher levels of IL-8, IL-6, IL1, and leukotriene B4 have been observed in the epithelial lining fluid compared to healthy controls (50)
Li et al
