glutathione causes bad breath IV Detox: Is It Right? Current Insights into Glutathione Depletion
Description
Glutathione deficiency leads to an increase in oxidative stress, accumulation of toxins and heavy metals

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Methods In this study, we design a two-in-one ferroptosis-inducing nanoplatform using iron-based metal-organic framework (MOF) that combines iron supply and GPX4 deactivation by loading the small molecule buthionine sulfoxide amine (BSO) to block de novo GSH biosynthesis, which can achieve sustainable GSH elimination and dual ferroptosis amplification

Di Paola R, Modafferi S, Siracusa R, et al
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