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At the end of the three-month study, both groups had a significant reduction in Leeds assessment of neuropathic symptoms and signs (LANSS) and Douleur Neuropathique (DN4) scores, but there was no significant difference between groups [39,40]

We have shown previously that sirtuins SIRT1 and SIRT3 have anti-fibrotic function, and their decreased tissue expression observed in skin biopsies from SSc patients, might directly contribute to the persistence of fibrosis 28,29

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S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies

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