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Salim Kanaan, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Until proper human trials are conducted, users are essentially volunteering as test subjects in an uncontrolled experiment with their own bodies.

October 24, 2003

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In these individuals it would appear that whilst they were able to exist as relatively healthy individuals, often not knowing that they had methylation associated mutations, some initiating factor such as a prolonged infection, combined with low vitamin D levels resulted in gradual loss of their vitamin B12 supplies leading to the CFS symptomatology being apparent, and the subsequent discovery of their methylation status

Additionally, B12 is essential for the conversion of homocysteine to methionine, preventing the accumulation of homocysteine, which is associated with cardiovascular risk
