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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Turnlund JR, King JC, Gong B, Keyes WR, Michel MC

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Upon binding of leptin to its extracellular domain, homodimerized LepRb undergoes a conformational change that enables the activation of JAK2, which then phosphorylates other tyrosine residues within the LepRbJAK2 complex to activate downstream signalling cascades 31,32 (FIG
1992), and increased beta-carotene levels in the blood also were found in human alcoholics (Ahmed et al
