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Variability of L-thyroxine replacement dose in elderly patients with primary hypothyroidism

Iron metabolism plays a central role, as excessive intracellular iron promotes the Fenton reaction, generating lethal amounts of ROS that drive lipid peroxidation [5]

Researchers have found that human proximal tubule epithelial cell lines exhibited distinct ultrastructural alterations indicative of pyroptosis when exposed to high glucose, and that the expression of TLR4, NLRP3, caspase-1, GSDMD-N, IL-1, and IL-18 are significantly upregulated (124)

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Yet, individual responses to supplements may differ

10.1056/NEJMra1215233 6 ArcherS