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They also act on the central nervous system , especially regions of the brain involved in appetite, motivation, and reward
GLP-1 receptors are present in vascular tissue, and their activation may improve endothelial function
SCFAs directly stimulate a GLP-1 release
Clinicians should counsel patients that full therapeutic effects on HbA1c and weight may not be apparent until 12 to 16 weeks after initiation
1994 Mar 1;120(5):441442
There is a black box warning for this class regarding the risk of osteosarcoma (bone cancer), which has been observed in animal models at high doses
