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In that study, db/db mice treated with metformin in the drinking water for two weeks displayed improvements in glycocalyx barrier properties when compared to control mice

Its identification as the first selenoenzyme, and the current understanding of its enzymology are discussed in a separate article in this issue (Floh et al., special issue)

Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A

[0472] In certain embodiments, the chimeric fusion proteins of the present invention are synthesized using recombinant DNA methodology

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