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PMID 27282957

Magnesium plays a key role in how nerves communicate with muscles and in regulating muscle contraction

doi: 10.1210/jc.2015-2222 243 Blow PedersenIKnudsenNCarlASchomburgLKhrleJJrgensenTet al

Additionally, its stress reducing properties, through stabilizing the hypothalamic-pituitary-adrenal (HPA) axis and lowering cortisol levels, help reduce inflammation and tension that can exacerbate pain

doi: 10.1084/jem.173.2.287

In addition, during senescence there is an increase in circulating innate immune cells (monocytes/macrophages, neutrophils), as well as an increase in proinflammatory cytokines, indicating an increased innate immune response, which is associated with an increased inflammatory response (Roubenoff et al., 1998