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Signs of cobalamin deficiency in dogs A dog with cobalamin deficiency may have one or more of the following symptoms: Lethargy Loss of appetite Change in eating habits Dull coat Loss of muscle mass Weight loss Weakness Diarrhea Loss of interest in playing Failure to thrive Mental dullness Seizures Cobalamin deficiency in dogs primarily occurs when there is a problem with cobalamin absorption

2 This is to compensate for the zinc that is secreted in breast milk

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The exact association between the position of mutation and clinical phenotypes is yet unknown, as a biallelic loss-of-function mutation in any part of the protein results in extreme enzyme deficiency