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Description
No published results from the one Phase II trial that was actually conducted

The SHMT1 encoded enzyme is cytosolic and the SHMT2 encoded enzyme is mitochondrial

Anemia happens when there arent enough red blood cells or theyre not good enough

Notably, the oxidation of dihydro-orotate to orotate integrates nucleotide synthesis, which is required to sustain the uncontrolled proliferation of cancer cells, with ROS production by the ETC, which drives cancer initiation and progression

Nutrients, 11 (3), 649

2022;16:ii73ii94
