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ISSN 1469-493X
Cancer Res 62(24):7264-72, 2002
et al., 2021
Without co-stimulatory signals on the antigen-presenting cell (in this case the cancer cell), CD4+ T cells will not differentiate into effector cells in response to antigens, which prevents an effective immune response
Examples [edit] In the late 1990s, evidence began accumulating to suggest that some GPCRs are able to signal without G proteins
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