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The -chain aggregates could produce reactive oxygen species, leading to oxidative stressinduced red blood cell (RBC) senescence [3].The basic clinical symptom of -thalassemia major is chronic anemia, which reduces the number of RBCs and hemoglobin (Hb) content, resulted from hemolysis and a deficiency in Hb production When RBCs are destroyed within the vascular compartment, Hb escapes into the plasma, dimerizes, and is rapidly bound by the serum protein haptoglobin (Hp)

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Some CYPs are specific for one or a few substrates, but others can act on many different substrates

These complications can have a significant impact on the quality of life and can lead to premature mortality

Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones
