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Ashwagandha may work by interacting with components of the proinflammatory cell signaling pathway, such as NF-B, signaling kinases, HSP90, Nrf2, and the inflammasome complex, even though the mechanisms behind the anti-inflammatory effect of withanolides are not fully understood (71)
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J Neurosci 29:88288838
Similar patterns of FTH1 upregulation and TfR1 downregulation have also been reported in primary murine chondrocytes under iron overload (93) and in cartilage tissue from OA models (94)
