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It is a naturally occurring copper-binding tripeptide that was first identified in human plasma

We induced abdominal compartment syndrome (intra-abdominal pressure in thiopental-anesthetized rats at 25 mmHg (60 min), 30 mmHg (30 min), 40 mmHg (30 min), and 50 mmHg (15 min) and in esketamine-anesthetized rats (25 mmHg for 120 min)) as a model of multiple occlusion syndrome

PMID 514474)

Contrary to expectations 86 , CV event rate (including stroke) in SELECT was in line with that described in GLP-1RA CVOT conducted in patients with diabetes 84,85

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