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Beyond cholesterol, factors such as chronic inflammation, autoimmune responses, hormonal imbalances, toxin exposure, genetics, and infections play vital roles

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Therefore, it can be deduced that exogenous H 2 S plays a double-edged sword role in HCC cells through regulating angiogenesis and apoptosis via EGFR/ERK/MMP-2 and PTEN/AKT pathways (Wu et al., 2017)