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The integrated PK-PD findings, including nonlinear exposure, target tissue accumulation, and disruption of L-carnitine homeostasis, collectively elucidate mildronates mechanism of action through energy substrate depletion, as well as its intrinsic efficacy-toxicity duality

Moreover, LA may enhance fatty acid oxidation by modulating the PPAR pathway, as activated PPAR induces the expression of genes related to fatty acid oxidation [74]

Albumen pH was significantly increased with FO inclusion to the LE diet compared to a diet containing SO or PO, or the NE diet

10.1007/s00417-022-05869-2 163 SchiffmanR

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doi:10.1128/mBio.02481-14 18