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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Berger, F., Lau, C., Dahlmann, M

If lifestyle measures are insufficient , your GP may recommend: Osmotic laxatives (such as macrogol) are often recommended as first-line treatment for chronic constipation Bulk-forming laxatives (such as ispaghula husk) may be suitable when stools are small and hard, particularly with IBS-like symptoms Stimulant laxatives (such as senna or bisacodyl) for short-term use in resistant cases According to NICE Clinical Knowledge Summaries , laxatives should be used appropriately and reviewed regularly

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Longer telomeres, in controlled contexts, are associated with extended cellular vitality

Epithalon has demonstrated a good safety profile in experimental and limited human studies, showing minimal adverse effects when used properly in research settings

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