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[DOI] [PMC free article] [PubMed] [Google Scholar] Kalk NJ, LingfordHughes AR (2014) The clinical pharmacology of acamprosate

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In KCs, SIRT1 deacetylates the NF-B p65 subunit, inhibiting its transcriptional activity and reducing the expression of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6