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Furthermore, it is noteworthy that in the SELECT trial, a 39.8-month follow-up trial in patients with cardiovascular disease and overweight or obesity, but not diabetes, 46 semaglutide 2.4 mg was superior to placebo in reducing the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke (HR 0.80

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0.96%, in that order) [90]

doi: 10.3748/wjg.v24.i12.1343

p53 activation effect in the balance of T regulatory and effector cell subsets in patients with thyroid cancer and autoimmunity