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A meta-analysis (Yu et al., 2015) revealed higher methylation rates of CDH1 in stages III and IV compared to stages I and II, suggesting its potential as an early screening biomarker for LC
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doi: 10.1016/j.neubiorev.2015.12.006 109 SeryoginaESKamyninaAVKoroevDOVolpinaOMVinokurovAYAbramovAY
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It promotes protein synthesis, reduces muscle breakdown, and directs the body to prioritize fat stores for energy
It also causes widespread oxidative damage to neuronal macromolecules, significantly contributing to the characteristic selective striatal neuronal loss in HD
