glutathione depletion paracetamol PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses Divergent effects of glutathione depletion

While doctors commonly use it to treat those who overdose on paracetamol (acetaminophen, Tylenol), it appears that supplementing with NAC and/or its precursor glutathione may have additional health benefits

Timeline of expected results Understanding when to expect results prevents premature protocol abandonment and helps researchers assess whether their approach is working

How much BAC water for peptides

The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased

10.1136/bmj.n1430

It's still at the infancy