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Gastroenterology 137, 466481 (2009)

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Additionally, the authors acknowledge the general positive bias of the published results, the lack of replicative validation studies, and the resulting risk of overestimating treatment efficacy in preclinical models that would provide confidence for the current findings and improve translational significance

Similar metabolic perturbations and cell necrosis were evident in cancer tissue interfered by selenite in in vivo experiments, suggesting that selenite is also a potential therapeutic direction to affect lung carcinogenesis through targeting GLS (31)

That last point gets missed often

Avoid mixing copper peptides with strong, lowpH actives like highstrength vitamin C (ascorbic acid), aggressive AHAs/BHAs (glycolic, lactic, salicylic acid), and potent retinoids in the same step, as they can destabilize peptides or increase irritation