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For instance, the MNA levels in serum were found increased in the obese people [22] and the MNA levels in urine were found increased both in obese db/db mice and in obese Zucker rats [21]

doi:10.1007/978-1-4419-7104-3_4

NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor

Studies have examined the relationship between NNMT inhibition and cellular NAD+ levels, which are critical for numerous enzymatic reactions including those involving sirtuins and PARPs
Elevated NNMT expression often correlates with altered metabolic states
