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In non-malignant T cells, such as activated CD4 + T cells and CTL cells, BCAT c accounts for 50% of the total BCAT expression level, whereas this proportion is upregulated to 60% in T-cell lymphomas

JAMA 302: 638648, 2009

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Longterm activation of MC1R, either physiologically or pharmacologically, has not been associated with increased incidence of melanoma, whereas lossoffunction variants in MC1R have been associated with an increased risk of melanoma