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By catalyzing the phosphorylation and degradation of IkB at specific amino acid residues, NFkB can translocate from the cytoplasm to the nucleus and further activate immune mediators such as IL-6 and IL-8 (122)

This drop closely correlates with the well-known reduction in regenerative capacity seen across multiple organ systems as we age

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KPV is recognized for its ability to reduce inflammation and support the immune system by inhibiting the activation of NF-kappaB and MAP kinase inflammatory pathways and decreasing proinflammatory cytokine secretion