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J Mol Cel Cardiol 23:13511354 Nygrd O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, Ueland PM, Kvle GJJ (1995) Total plasma homocysteine and cardiovascular risk profile: the Hordaland Homocysteine Study

One of the main molecular pathologic mechanisms in this setting is represented by -synuclein aggregation in mitochondria, which leads to the production of reactive oxygen species (ROS) and induces activation of p38 MAPK, a MAP-kinase that triggers the phosphorylation of Drp1 (dynamin-related protein-1), which eventually leads to mitochondrial fission (Filichia et al., 2016)

Researchers are exploring innovative strategies for neurodegenerative disorders, with EGCG emerging as a promising compound

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10.1111/j.1745-7254.2005.00081.x 85 LiuJ.LiM.WangY.LuoJ