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In conclusion, nanotechnology offers promising avenues for advancing GB treatment by addressing key challenges such as BBB penetration, targeted drug delivery, and overcoming drug resistance

10.1016/j.jsbmb.2018.10.017 138

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The concept of a muscle-liver-vasculature axis is gaining traction, where lipotoxins produced in insulin-resistant muscle (e.g., specific ceramide species) can be released into the circulation, potentially influencing hepatic VLDL secretion and directly affecting endothelial function ( Figure 4 )